The U-251 MG cell line, previously known as U-373 MG, is a human glioblastoma cell line derived from a brain tumor in a 58-year-old male patient. Glioblastoma, also known as glioblastoma multiforme (GBM), is an aggressive and highly malignant primary brain tumor that originates from glial cells, specifically astrocytes. Glioblastomas are characterized by rapid growth and poor prognosis, with an average survival time of about 15 months following diagnosis, even with aggressive treatment options.

The U-251 MG cell line serves as an in vitro model system for studying glioblastoma biology, molecular mechanisms, and potential therapeutics. Researchers have employed this cell line in various studies to investigate the role of oncogenes, tumor suppressor genes, and signaling pathways in glioblastoma development and progression. Additionally, U-251 MG cells have been used to test the efficacy of potential anti-cancer drugs and to study drug resistance mechanisms specific to glioblastoma.

It is important to note that the original U-373 MG cell line was found to be cross-contaminated with the U-251 MG cell line. As a result, the cell line formerly known as U-373 MG is now referred to as U-251 MG. Researchers should ensure the cell line’s identity and relevance to their experimental objectives before using it in their studies.

In summary, the U-251 MG cell line is a valuable tool for researchers working in the field of brain cancer, as it provides insights into the biology and molecular mechanisms underlying glioblastoma and supports the development and testing of potential therapeutic strategies.